Innate immunity

Hycult Biotech presents a specific assay for the quantification of human MASP-3 in plasma (Cat.# HK339)

MASP-3 is an alternatively spliced product from the MASP-1 gene, containing an identical A chain, but an entirely different B chain. MASP-3 is an approximately 100 kD protein and associates with both MBL and L-ficolin in the presence of Ca2+.

MASP-3 function
Unlike MASP-2, no proteolytic activity on complement proteins C2, C3 and C4 for MASP-3 has been detected. MASP-3 exerts inhibitory activity on MASP-2 function.

MASP-3 expression
MASP-3 is expressed mainly but not exclusively in the liver and is secreted into the blood. The high expression of MASP-3 in astrocytes indicates that MASP-3 might also be involved in other functions that could be important in the brain.

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Inflammation

sMAdCAM-1 as biomarker for inflammatory activity
(Cat. # HK337)

The Hbt sMAdCAM-1 ELISA allows sensitive and accurate quantification of sMAdCAM-1 in  plasma, urine and mother milk. The assay can be used for non-invasive studies on diverse inflammatory diseases and disease states.

 
Figure: MAdCAM-1 in the intestinal endothelium of a patient with Crohn’s disease. Staining of paraffin-embedded section with antibody 314G8.  (Cat# HM2207)

Cell- and tissue damage

I-FABP is a promising marker to assess enterocyte injury
(Cat.# HK406)

A recent study showed that urinary I-FABP, measured using ELISA, prospectively identified neonates with necrotizing enterocolitis (NEC).

Urinary I-FABP levels in neonates can predict NEC

Organ and tissue-related research

Novel monoclonal antibody against PMP22, a marker for peripheral myelin sheaths
(Cat.# HM2219)

Peripheral myelin protein 22 (PMP22) is the second most abundant protein in the mammalian nervous system.  

Other

Mouse mAb isotyping kit
(Cat.# HL2010/2020)

An easy one-step procedure for the determination of the isotype of mouse monoclonal antibodies (heavy and light chains).