Innate immunity

Human, rat and mouse C1q ELISA: a reliable measurement

Specifications of human C1q ELISA (Cat.# HK356)

Detection limit of 15.6 ng/ml
Useful for serum, plasma and BAL
Detection of unbound C1q as well as C1q-immunocomplexes (CIC)

Deficiency of C1q is directly linked to SLE and glomerulonephritis due to congenital deletions
Decrease in C1q serum levels results in reduced uptake of apoptotic cells
The decrease of phagocytosis results in increased autoimmunity resulting in more circulating auto-antibodies

Click here to read more about the C1q ELISA

Inflammation

The human acute phase SAA as inflammatory marker

Unique assay for measurement in urine (Cat.#HK333)
Human SAA concentration rises earlier and sharper than acute phase protein CRP
SAA is linked to inflammation, atherosclerosis, thrombosis, AA-amyloidosis, rheumatoid arthritis, and neoplasia.

Cell- and tissue damage

Knocking out LOX-1 limits myocardial ischemia-reperfusion injury in mice.

Lectin-like oxidized low-density lipoprotein receptors (e.g LOX-1) are upregulated during myocardial ischemia-reperfusion, and appear to be associated with apoptosis, necrosis, and left ventricular functional deterioration. (Cat.# HM2138)

Organ and tissue-related research

Unique antibodies for functional studies on mouse basophils and mast cells

Depletion of basophils by Ba103 and Ba91, antibodies recognizing CD200R3 (Cat.# HM1103 and Cat.# HM1104)

Figure Nat Immunol 2008, 9: 223

Other

Human NGAL ELISA: a quantitative assay for the detection of epithelial injury

NGAL ELISA (Cat. # HK330) allows sensitive and accurate quantification of NGAL in plasma and urine.