Innate immunity
Hycult Biotech presents a specific assay for the quantification of human MASP-3 in plasma (Cat.# HK339)
MASP-3 is an alternatively spliced product from the MASP-1 gene, containing an identical A chain, but an entirely different B chain. MASP-3 is an approximately 100 kD protein and associates with both MBL and L-ficolin in the presence of Ca2+.
MASP-3 function
Unlike MASP-2, no proteolytic activity on complement proteins C2, C3 and C4 for MASP-3 has been detected. MASP-3 exerts inhibitory activity on MASP-2 function.
MASP-3 expression
MASP-3 is expressed mainly but not exclusively in the liver and is secreted into the blood. The high expression of MASP-3 in astrocytes indicates that MASP-3 might also be involved in other functions that could be important in the brain.
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