Toll like receptors, human

Toll like receptors (TLRs) are a class of non-catalytic receptors that function as patternrecognition receptors (PRRs). These receptors recognize pathogen-associated molecular patterns (PAMPs) that are shared by large groups of microorganisms, but also endogenous alarm signals, like apoptosis related membrane fragments and inflammatory ligands. Common cytoplasmic domains allow TLRs to use the same signaling molecules used by the interleukin-1 receptors (IL-1Rs), including MyD88 and TRIF. In man both intracellular and extracellular TLR exist. The intracellularly located TLR9 confers responses to bacterial DNA via species-specific CpG-motif recognition. Therefore, CpG-DNA can be used to investigate TLR9 response in various systems.

Product	Quantity	Application	Cat #
CD180, Human, mAb MHR73	100 µg	F FC FS IP	HM2083
CD180, Human, mAb MHR73, biotinylated	50 µg	F FC	HM2084
CD180, Human, mAb MHR73, FITC	100 µg	F FC FS IP	HM2083F
sMD-2 and sMD-2/TLR4, Human, mAb 4H1	100 µg	FS IA W IF	HM2243
sMD-2, Human, mAb 10D5	100 µg	IA W IF	HM2244
TLR 4, Human, mAb 3C3, biotinylated	50 µg	FC	HM2247BT
TLR1, Human, mAb GD2.F4	100 µg	FC	HM2085
TLR1, Human, mAb GD2.F4, biotinylated	50 µg	FC	HM2086
TLR1, Human, mAb GD2.F4, FITC	100 µg	FC	HM2085F
TLR2, Human, mAb TL2.1 Cross reactivity: canine, cynomologus monkey, marmoset monkey, rhesus monkey	100 µg	F FC FS IP P W	HM2064
TLR2, Human, mAb TL2.1, biotinylated Cross reactivity: canine, cynomologus monkey, marmoset monkey, rhesus monkey	50 µg	F FC IA P W	HM2065
TLR2, Human, mAb TL2.1, FITC Cross reactivity: canine, cynomologus monkey, marmoset monkey, rhesus monkey	100 µg	F FC P W	HM2064F
TLR2, Human, mAb TL2.3	100 µg	FC IA W	HM2066
TLR2, Human, mAb TL2.3, biotinylated	50 µg	FC IA W	HM2067
TLR2, Human, mAb TL2.3, FITC	100 µg	FC	HM2066F
TLR2, Human, mAb TLR2.45	100 µg	IF	HM2220F
TLR2, Human, mAb TLR2.45	100 µg	IF	HM2220
TLR2, Human, mAb TLR2.45, biotinylated	50 µg	IF	HM2220BT
TLR3, Human, mAb TLR3.7	100 µg	FC FS W	HM2096
TLR3, Human, mAb TLR3.7, biotinylated	50 µg	FC W	HM2097
TLR3, Human, mAb TLR3.7, FITC	100 µg	FC W	HM2096F
TLR4, Human, mAb 3C3	100 µg	FC FS	HM2247
TLR4, Human, mAb 3C3, FITC	100 µg	FC	HM2247F
TLR4, Human, mAb HTA125 Cross reactivity: canine, cynomologus monkey, marmoset monkey, rhesus monkey	100 µg	F FC FS IP	HM2068
TLR4, Human, mAb HTA125, biotinylated Cross reactivity: canine, cynomologus monkey, marmoset monkey, rhesus monkey	50 µg	F FC	HM2069
TLR4, Human, mAb HTA125, FITC Cross reactivity: canine, cynomologus monkey, marmoset monkey, rhesus monkey	100 µg	FC	HM2068F
TLR4/MD-2, Human, mAb 7E3	100 µg	FC FS	HM2246
TLR4/MD-2, Human, mAb 7E3, biotinylated	50 µg	FC	HM2246BT
TLR4/MD-2, Human, mAb 7E3, FITC	100 µg	FC	HM2246F
TLR5, Human, mAb 19D759.2	100 µg	F FC P W IF	HM2159
TLR5, Human, mAb 19D759.2, FITC	100 µg	F FC P W IF	HM2159F
TLR6, Human, mAb TLR6.127	100 µg	IF	HM2221
TLR6, Human, mAb TLR6.127, biotinylated	50 µg	IF	HM2221BT
TLR6, Human, mAb TLR6.127, FITC	100 µg	IF	HM2221F
TLR7, Human, pAb	100 µg	F FC IP W IF	HP9040
TLR8, Human, mAb 44C143	100 µg	FC P W IF	HM2160
TLR8, Human, mAb 44C143, FITC	100 µg	FC P W IF	HM2160F
TLR9, Human, mAb 5G5 Cross reactivity: canine, mouse	100 µg	F FC IA W	HM2087
TLR9, Human, mAb 5G5, biotinylated Cross reactivity: canine, mouse	50 µg	F FC IA W	HM2088
TLR9, Human, mAb 5G5, FITC Cross reactivity: canine, mouse	100 µg	F FC IA W	HM2087F

For research purposes only. Not for drug, diagnostic or other use.

F: Frozen sections
FC: Flow cytometry
FS: Functional studies
IA: Immuno assays
IF: Immuno fluorescence
IP: Immuno precipitation
P: Paraffin sections
W: Western blot

Protocols