Lectin-like molecules

Mannose-Binding Lectin (MBL) also called mannan-binding lectin, mannose- or mannan-binding protein (MBP) is a member of the collectins and an important element in innate immunity. It forms a complex with C1r/C1s like serine proteases designated MASP that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative pathways.
MBL exhibits complement-dependent anti-bacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL-deficiency has been related to a number of diseases. Measurement of functional MBL is of interest in studies on bacterial infections, autoimmune diseases, cancer, HIV, transplantation, atherosclerosis, cystic fibrosis, transplantation and many other diseases.
HBT offers antibodies and assays to human MBL, unique assays for mouse MBL-A and MBL-C, MASP2, and MBL/MASP2.

Product	Quantity	Application	Cat #
Hycult Dx Human MBL ELISA kit	1 x 96 det.		DH001
MBL, Human, ELISA kit	2 x 96 det.		HK323
MBL, Human, mAb 3E7	100 µg	F FC IA W	HM2061
MBL, Human, mAb 3E7, FITC	100 µg	F FC IA W	HM2061F
MBL, Human, mAb D8.18	100 µg	FC IA W	HM2081
MBL, Human, mAb D8.18, biotinylated	50 µg	FC IA W	HM2082
MBL-A, Mouse, ELISA kit	2 x 96 det.		HK208
MBL-A, Mouse, mAb 2B4	100 µg	IA W	HM1036
MBL-A, Mouse, mAb 8G6	100 µg	F IA W	HM1035
MBL-C, Mouse, ELISA kit	2 x 96 det.		HK209
MBL-C, Mouse, mAb 14D12	100 µg	F IA W	HM1038
MBL-C, Mouse, mAb 16A8	100 µg	IA W	HM1037

For research purposes only. Not for drug, diagnostic or other use.

F: Frozen sections
FC: Flow cytometry
FS: Functional studies
IA: Immuno assays
IF: Immuno fluorescence
IP: Immuno precipitation
P: Paraffin sections
W: Western blot

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